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Metabolic reprogramming in polycystic kidney disease

A recent study shows that, like cancer cells, cells lacking the Pdk1 gene reprogram their metabolism to use aerobic glycolysis—the 'Warburg effect'. Targeting this pathway using a glucose analog that cannot be metabolized resulted in slower disease progression in mouse models of polycystic kidney disease. This work thus suggests a new potential therapeutic approach for autosomal dominant polycystic kidney disease (pages 488–493).

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Figure 1: Pkd1-deficient cells use the Warburg effect to fuel their proliferation.

Katie Vicari


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Correspondence to Elizabeth P Henske.

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Priolo, C., Henske, E. Metabolic reprogramming in polycystic kidney disease. Nat Med 19, 407–409 (2013).

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