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TNF-α trips up Treg cells in rheumatoid arthritis

Regulatory T (Treg) cells are important for protecting against pathogenic T cell responses, and impaired Treg functions have been linked with autoimmune diseases. A recent study reveals a new mechanism for the inflammatory cytokine tumor necrosis factor-α (TNF-α) in rheumatoid arthritis, showing that it disables Treg cells by affecting the phosphorylation and function of a key transcription factor expressed in these cells (pages 322–328).

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Figure 1: Regulation of FOXP3 phosphorylation mediates Treg suppressive function in rheumatoid arthritis.

Marina Corral


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Correspondence to Jonathan Bromberg.

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Bromberg, J. TNF-α trips up Treg cells in rheumatoid arthritis. Nat Med 19, 269–270 (2013).

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