Turning off the inflammatory, but not the metabolic, flames

Metabolically driven, chronic, low-grade inflammation has a crucial role in the pathogenesis of obesity and type 2 diabetes, and multiple stress-signaling cascades link insulin resistance and the immune response. An approved immunomodulatory drug is now shown to inhibit the kinases IKKε and TBK1, suppress inflammation and improve metabolic homeostasis in mouse models of obesity (pages 313–321).

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Figure 1: Signaling pathways involved in classical inflammation and metaflammation.

Marina Corral

Change history

  • 22 March 2013

     In the version of this article initially published, TBK1 was incorrectly referred to in a number of instances as TKB1. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1

    Gregor, M.F. & Hotamisligil, G.S. Annu. Rev. Immunol. 29, 415–445 (2011).

  2. 2

    Olefsky, J.M. & Glass, C.K. Annu. Rev. Physiol. 72, 219–246 (2010).

  3. 3

    Odegaard, J.I. & Chawla, A. Science 339, 172–177 (2013).

  4. 4

    Johnson, A.R., Milner, J.J. & Makowski, L. Immunol. Rev. 249, 218–238 (2012).

  5. 5

    Hirosumi, J. et al. Nature 420, 333–336 (2002).

  6. 6

    Yuan, M. et al. Science 293, 1673–1677 (2001).

  7. 7

    Arkan, M.C. et al. Nat. Med. 11, 191–198 (2005).

  8. 8

    Nakamura, T. et al. Cell 140, 338–348 (2010).

  9. 9

    Carvalho-Filho, M.A. et al. Endocrinology 153, 5261–5274 (2012).

  10. 10

    Reilly, S.M. et al. Nat. Med. 19, 313–321 (2013).

  11. 11

    Baker, R.G., Hayden, M.S. & Ghosh, S.N.F. Cell Metab. 13, 11–22 (2011).

  12. 12

    Chiang, S.-H. et al. Cell 138, 961–975 (2009).

  13. 13

    Scheja, L., Heese, B. & Seedorf, K. Biochem. Biophys. Res. Commun. 407, 288–294 (2011).

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Correspondence to Gökhan S. Hotamisligil.

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Calay, E., Hotamisligil, G. Turning off the inflammatory, but not the metabolic, flames. Nat Med 19, 265–267 (2013). https://doi.org/10.1038/nm.3114

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