Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Community Corner
  • Published:

Exploring the epigenetics of cocaine resistance

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout


  1. Vassoler, F.M. et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat. Neurosci. 16, 42–47 (2013).

    Article  CAS  Google Scholar 

  2. Ghitza, U.E. et al. Role of BDNF and GDNF in drug reward and relapse: a review. Neurosci. Biobehav. Rev. 35, 157–171 (2010).

    Article  CAS  Google Scholar 

  3. Berglind, W.J. et al. A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. Eur. J. Neurosci. 26, 757–766 (2007).

    Article  Google Scholar 

  4. D'Sa, C., Fox, H.C., Hong, A.K., Dileone, R.J. & Sinha, R. Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study. Biol. Psychiatry 70, 706–711 (2011).

    Article  CAS  Google Scholar 

  5. Nagahara, A.H. & Tuszynski, M.H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat. Rev. Drug Discov. 10, 209–219 (2011).

    Article  CAS  Google Scholar 

  6. Anway, M.D., Cupp, A.S., Uzumcu, M. & Skinner, M.K. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308, 1466–1469 (2005).

    Article  CAS  Google Scholar 

  7. Skinner, M.K., Manikkam, M. & Guerrero-Bosagna, C. Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol. Metab. 21, 214–222 (2010).

    Article  CAS  Google Scholar 

  8. Guerrero-Bosagna, C., Settles, M., Lucker, B. & Skinner, M. Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS ONE 5, e13100 (2010).

    Article  Google Scholar 

  9. Pawlow, I.P. New researches on conditioned reflexes. Science 58, 359–361 (1923).

    Article  CAS  Google Scholar 

  10. Bonduriansky, R. Rethinking heredity, again. Trends Ecol. Evol. 27, 330–336 (2012).

    Article  CAS  Google Scholar 

  11. Gogineni, A. et al. Female offspring of alcoholic individuals: recent findings on alcoholism and psychopathology risks: symposium presented at the Research Society on Alcoholism, 2004, Vancouver Aruna Gogineni, Chair. Alcohol. Clin. Exp. Res. 30, 377–387 (2006).

    Article  Google Scholar 

  12. Deroche-Gamonet, V., Belin, D. & Piazza, P.V. Evidence for addiction-like behavior in the rat. Science 305, 1014–1017 (2004).

    Article  CAS  Google Scholar 

  13. Hammoud, S.S. et al. Distinctive chromatin in human sperm packages genes for embryo development. Nature 460, 473–478 (2009).

    Article  CAS  Google Scholar 

  14. Shulha, H.P. et al. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 10, e1001427 (2012).

    Article  CAS  Google Scholar 

Download references

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Exploring the epigenetics of cocaine resistance. Nat Med 19, 136–137 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing