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RNA editing enters the limelight in cancer

Nature Medicine volume 19, pages 130–131 (2013)Cite this article

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There has been much focus on DNA mutations in tumorigenesis and tumor progression, but now a new study highlights a role for post-transcriptional changes in RNA in cancer. The authors show increased RNA editing of antizyme inhibitor 1 (AZIN1) in tumor tissues from patients with hepatocellular carcinoma and characterize a mechanism through which the expression of edited AZIN1 protein leads to increased cell proliferation (pages 209–216).

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Figure 1: Regulation of cell proliferation by RNA editing of AZIN1 in HCC.

Marina Corral

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  1. Angela Gallo is at the Bambino Gesù Children's Hospital IRCCS, Rome, Italy.,

    Angela Gallo

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  1. Angela Gallo
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Correspondence to Angela Gallo.

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Gallo, A. RNA editing enters the limelight in cancer. Nat Med 19, 130–131 (2013). https://doi.org/10.1038/nm.3072

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