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Compacting the heart with Notch

Nature Medicine volume 19, pages 133–134 (2013)Cite this article

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Left ventricular noncompaction (LVNC) cardiomyopathy is a clinically and genetically heterogeneous disease that can be associated with substantial cardiovascular morbidity and mortality. A new study shows that mice with myocardial deletion of Mib1, which encodes a ubiquitin ligase in the Notch signaling pathway, have LVNC phenotypes and identifies MIB1 mutations in humans with LVNC (pages 193–201).

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Figure 1: Development of the myocardial compact layer during stages of cardiac morphogenesis.

Marina Corral

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Authors and Affiliations

  1. Chaitali Misra and Vidu Garg are at the Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.,

    Chaitali Misra & Vidu Garg

  2. Vidu Garg is also in the Departments of Pediatrics and Molecular Genetics, The Ohio State University, Columbus, Ohio, USA.,

    Vidu Garg

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  1. Chaitali Misra
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  2. Vidu Garg
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Correspondence to Vidu Garg.

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The authors declare no competing financial interests.

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Misra, C., Garg, V. Compacting the heart with Notch. Nat Med 19, 133–134 (2013). https://doi.org/10.1038/nm.3071

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