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Alzheimer's γ-secretase under arrestin

Nature Medicine volume 19, pages 22–24 (2013)Cite this article

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Production of the amyloid-β peptide in Alzheimer's disease by the γ-secretase complex can be regulated by certain G protein–coupled receptors. This regulation seems to be mediated by β-arrestin-2, whose expression was found to be elevated in Alzheimer's disease brains (pages 43–49).

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Figure 1: Model for the role of β-arrestin 2 in the localization and activation of γ-secretase and Aβ production in Alzheimer's disease.

Marina Corral

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  1. Michael S. Wolfe is at the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.,

    Michael S Wolfe

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  1. Michael S Wolfe
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Correspondence to Michael S Wolfe.

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Wolfe, M. Alzheimer's γ-secretase under arrestin. Nat Med 19, 22–24 (2013). https://doi.org/10.1038/nm.3053

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