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Enhancing hematopoietic growth factor performance

Delayed blood count recovery is a major cause of morbidity and mortality in people undergoing stem cell transplantation or intensive chemotherapy. Treatment with hematopoietic growth factors can accelerate hematopoiesis, but prolonged cytopenias still occur. A new study shows that inhibition of dipeptidylpeptidase IV augments the activity of certain hematopoietic growth factors, providing a new approach to potentially treat cytopenias (pages 1786–1796).

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Figure 1: DPP4 regulation of HGF activity.

Debbie Maizels

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Correspondence to Daniel C Link.

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Hsu, YM., Link, D. Enhancing hematopoietic growth factor performance. Nat Med 18, 1740–1741 (2012). https://doi.org/10.1038/nm.3022

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