Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Hiding under the skin: Interleukin-17–producing γδ T cells go under the skin?

Despite the irrefutable role of inflammation in psoriasis, a complete knowledge of what immune cells and cytokines are involved during initiation and progression of this skin disease is lacking. Moreover, the complexities of the immune cell network and potential differences between mice and humans have led to translational failures. It is therefore important that we acquire in-depth understanding of what inflammatory players, of the many involved, are crucial, if we wish to develop effective therapies. In 'Bedside to Bench', James Krueger discusses how a subset of T cells, TH17 cells, which release interleukin-17 in humans, seem to be essential for pathogenesis of psoriasis. The interplay between interleukin-17 and other cytokines that may potentially be involved in psoriasis also needs further investigation. Additionally, there are open questions as to what subset of T cells, other than TH17, also produce interleukin-17 and when. In 'Bench to Bedside', Burkhard Becher and Stanislav Pantelyushin examine this issue by looking at a mouse model of skin inflammation that resembles psoriasis in humans. A class of skin-invading innate immune cells called γδ T cells was shown to drive skin inflammation in this model, particularly during the early stages of the disease, suggesting that innate immunity plays an important part in the initiation of psoriasis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Initiation of psoriasis by γδ T cells and ILCs.

Debbie Maizels

References

  1. 1

    Perera, G.K., Di Meglio, P. & Nestle, F.O. Annu. Rev. Pathol. 7, 385–422 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Gutcher, I. & Becher, B. J. Clin. Invest. 117, 1119–1127 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Boyman, O. et al. J. Exp. Med. 199, 731–736 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Blumberg, H. et al. J. Immunol. 185, 4354–4362 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Griffiths, C.E.M. et al. N. Engl. J. Med. 362, 118–128 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Gottlieb, A.B. et al. Br. J. Dermatol. 165, 652–660 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Hueber, W. et al. Sci. Transl. Med. 2, 52ra72 (2010).

    Article  Google Scholar 

  8. 8

    Leonardi, C. et al. N. Engl. J. Med. 366, 1190–1199 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Papp, K.A. et al. N. Engl. J. Med. 366, 1181–1189 (2012).

    CAS  Article  Google Scholar 

  10. 10

    Bissonnette, R. et al. J. Am. Acad. Dermatol. 62, 427–436 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Gilliet, M. et al. Arch. Dermatol. 140, 1490–1495 (2004).

    CAS  Article  Google Scholar 

  12. 12

    van der Fits, L. et al. J. Immunol. 182, 5836–5845 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Cai, Y. et al. Immunity 35, 596–610 (2011).

    CAS  Article  Google Scholar 

  14. 14

    Pantelyushin, S. et al. J. Clin. Invest. 122, 2252–2256 (2012).

    CAS  Article  Google Scholar 

  15. 15

    Laggner, U. et al. J. Immunol. 187, 2783–2793 (2011).

    CAS  Article  Google Scholar 

  16. 16

    Guo, L., Junttila, I.S. & Paul, W.E. Trends Immunol. published online, 10.1016/j.it.2012.07.006 (7 September 2012).

  17. 17

    Eberl, G. Immunol. Rev. 245, 177–188 (2012).

    CAS  Article  Google Scholar 

  18. 18

    Antoniu, S.A. Expert Opin. Investig. Drugs 21, 1607–1618 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Burkhard Becher.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Becher, B., Pantelyushin, S. Hiding under the skin: Interleukin-17–producing γδ T cells go under the skin?. Nat Med 18, 1748–1750 (2012). https://doi.org/10.1038/nm.3016

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing