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Can't get there from here: cilia and hydrocephalus

Nature Medicine volume 18, pages1742–1743(2012)Cite this article

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Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet–Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797–1804).

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Figure 1: Developmental mechanisms of communicating hydrocephalus in BBS.

Debbie Maizels

References

  1. 1

    Zhang, J., Williams, M.A. & Rigamonti, D. J. Neurol. 253, 1255–1266 (2006).

    CAS  Article  Google Scholar 

  2. 2

    Ibañez-Tallon, I. et al. Hum. Mol. Genet. 13, 2133–2141 (2004).

    Article  Google Scholar 

  3. 3

    Rekate, H.L. Semin. Pediatr. Neurol. 16, 9–15 (2009).

    Article  Google Scholar 

  4. 4

    Browd, S.R., Ragel, B.T., Gottfried, O.N. & Kestle, J.R. Pediatr. Neurol. 34, 83–92 (2006).

    Article  Google Scholar 

  5. 5

    Friedland-Little, J.M. et al. Hum. Mol. Genet. 20, 3725–3737 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Putoux, A. et al. Nat. Genet. 43, 601–606 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Carter, C.S. et al. Nat. Med. 18, 1797–1804 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Davis, R.E. et al. Proc. Natl. Acad. Sci. USA 104, 19422–19427 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Rivers, L.E. et al. Nat. Neurosci. 11, 1392–1401 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Kondo, T. & Raff, M. Science 289, 1754–1757 (2000).

    CAS  Article  Google Scholar 

  11. 11

    Richardson, W.D., Young, K.M., Tripathi, R.B. & McKenzie, I. Neuron 70, 661–673 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Tripathi, R.B., Rivers, L.E., Young, K.M., Jamen, F. & Richardson, W.D. J. Neurosci. 30, 16383–16390 (2010).

    CAS  Article  Google Scholar 

Download references

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Affiliations

  1. Bethany N. Sotak and Joseph G. Gleeson are at the Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, USA.

    Bethany N Sotak & Joseph G Gleeson

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  1. Bethany N Sotak
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  2. Joseph G Gleeson
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Correspondence to Joseph G Gleeson.

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The authors declare no competing financial interests.

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Sotak, B., Gleeson, J. Can't get there from here: cilia and hydrocephalus. Nat Med 18, 1742–1743 (2012). https://doi.org/10.1038/nm.3011

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