Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Can't get there from here: cilia and hydrocephalus

Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet–Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797–1804).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Developmental mechanisms of communicating hydrocephalus in BBS.

Debbie Maizels

References

  1. 1

    Zhang, J., Williams, M.A. & Rigamonti, D. J. Neurol. 253, 1255–1266 (2006).

    CAS  Article  Google Scholar 

  2. 2

    Ibañez-Tallon, I. et al. Hum. Mol. Genet. 13, 2133–2141 (2004).

    Article  Google Scholar 

  3. 3

    Rekate, H.L. Semin. Pediatr. Neurol. 16, 9–15 (2009).

    Article  Google Scholar 

  4. 4

    Browd, S.R., Ragel, B.T., Gottfried, O.N. & Kestle, J.R. Pediatr. Neurol. 34, 83–92 (2006).

    Article  Google Scholar 

  5. 5

    Friedland-Little, J.M. et al. Hum. Mol. Genet. 20, 3725–3737 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Putoux, A. et al. Nat. Genet. 43, 601–606 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Carter, C.S. et al. Nat. Med. 18, 1797–1804 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Davis, R.E. et al. Proc. Natl. Acad. Sci. USA 104, 19422–19427 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Rivers, L.E. et al. Nat. Neurosci. 11, 1392–1401 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Kondo, T. & Raff, M. Science 289, 1754–1757 (2000).

    CAS  Article  Google Scholar 

  11. 11

    Richardson, W.D., Young, K.M., Tripathi, R.B. & McKenzie, I. Neuron 70, 661–673 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Tripathi, R.B., Rivers, L.E., Young, K.M., Jamen, F. & Richardson, W.D. J. Neurosci. 30, 16383–16390 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Joseph G Gleeson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sotak, B., Gleeson, J. Can't get there from here: cilia and hydrocephalus. Nat Med 18, 1742–1743 (2012). https://doi.org/10.1038/nm.3011

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing