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Can't get there from here: cilia and hydrocephalus

Nature Medicine volume 18, pages 1742–1743 (2012)Cite this article

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Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet–Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797–1804).

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Figure 1: Developmental mechanisms of communicating hydrocephalus in BBS.

Debbie Maizels

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Authors and Affiliations

  1. Bethany N. Sotak and Joseph G. Gleeson are at the Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, USA.,

    Bethany N Sotak & Joseph G Gleeson

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  1. Bethany N Sotak
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  2. Joseph G Gleeson
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Correspondence to Joseph G Gleeson.

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The authors declare no competing financial interests.

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Sotak, B., Gleeson, J. Can't get there from here: cilia and hydrocephalus. Nat Med 18, 1742–1743 (2012). https://doi.org/10.1038/nm.3011

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