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Metabolic jet lag when the fat clock is out of sync

There is a growing appreciation of the importance of circadian regulation in energy homeostasis, and the dysregulation of the circadian clock has been associated with obesity and metabolic abnormalities. A new study shows that adipocyte-specific deletion of a core circadian clock gene, Arntl (Bmal1), in mice shifts the timing of their feeding behavior, resulting in obesity (pages 1768–1777).

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Figure 1: Effects of Arntl knockout in different cell types in mice.

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Acknowledgements

The authors are supported by the US National Institutes of Health (grants R01-DK55758 and P01DK088761-01 to P.E.S.). I.W.A. was also supported by a fellowship from the Throne-Holst Foundation and the Swedish Research Council (2006-3931) and by a VINNMER fellowship from the VINNOVA Foundation.

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Correspondence to Philipp E Scherer.

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Asterholm, I., Scherer, P. Metabolic jet lag when the fat clock is out of sync. Nat Med 18, 1738–1740 (2012). https://doi.org/10.1038/nm.3010

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