A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673–1681).
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Robinson, H., Amara, R. Protective immunity from a germinal center sanctuary. Nat Med 18, 1614–1616 (2012). https://doi.org/10.1038/nm.2986
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DOI: https://doi.org/10.1038/nm.2986