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A sirtuin link between metabolism and heart disease

Nature Medicine volume 18, pages 1617–1619 (2012)Cite this article

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The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643–1650).

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Figure 1: Derepression of IGF signaling–related genes and hypertrophic cardiomyopathy by SIRT6 deficiency.

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  1. Keith A. Webster is in the Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute at the University of Miami Miller School of Medicine, Miami, Florida, USA.,

    Keith A Webster

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  1. Keith A Webster
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Correspondence to Keith A Webster.

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Webster, K. A sirtuin link between metabolism and heart disease. Nat Med 18, 1617–1619 (2012). https://doi.org/10.1038/nm.2983

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