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Before Epilepsy Unfolds: Finding the epileptogenesis switch

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Figure 1: Pathophysiological cascade of mTOR-dependent events leading to epilepsy development.

References

  1. 1

    Han, J.M. & Sahin, M. FEBS Lett. 585, 973–980 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Crino, P.B. Trends Mol. Med. 17, 734–742 (2011).

    CAS  Article  Google Scholar 

  3. 3

    Galanoupoulou, A.S. et al. Epilepsia 53, 1119–1130 (2012).

    Article  Google Scholar 

  4. 4

    Feliciano, D.M. et al. J. Clin. Invest. 121, 1596–1607 (2011).

    CAS  Article  Google Scholar 

  5. 5

    Meikle, L. et al. J. Neurosci. 27, 5546–5558 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Sunnen, C.N. et al. Epilepsia 52, 2065–2075 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Zheng, L.-H. et al. J. Neurosci. 29, 6964–6972 (2009).

    Article  Google Scholar 

  8. 8

    Sha, L.-Z. et al. PLoS ONE 7, e39152 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Buckmaster, P.S. & Lew, F.H. J. Neurosci. 31, 2337–2347 (2011).

    CAS  Article  Google Scholar 

  10. 10

    Kwon, C.-H. et al. Proc. Natl. Acad. Sci. USA 100, 12923–12928 (2003).

    CAS  Article  Google Scholar 

  11. 11

    Huang, X. et al. Neurobiol. Dis. 40, 193–199 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Raffo, E. Neurobiol. Dis. 43, 322–329 (2011).

    CAS  Article  Google Scholar 

  13. 13

    Talos, D.M. et al. PLoS ONE 7, e35885 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Muncy, J. et al. J. Child Neurol. 24, 477 (2009).

    Article  Google Scholar 

  15. 15

    Krueger, D.A. et al. N. Engl. J. Med. 363, 1801–1811 (2012).

    Article  Google Scholar 

  16. 16

    Ryther, R.C.C. & Wong, M. Curr. Neurol. Neurosci. Rep. 12, 410–418 (2012).

    CAS  Article  Google Scholar 

  17. 17

    Zeng, L.-H. et al. Cell Cycle 9, 2281–2285 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Annamaria Vezzani.

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Vezzani, A. Before Epilepsy Unfolds: Finding the epileptogenesis switch. Nat Med 18, 1626–1627 (2012). https://doi.org/10.1038/nm.2982

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