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SAMHD1 does it again, now in resting T cells

A long-standing question in the HIV field is why HIV-1 fails to replicate in resting CD4+ T cells. A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile α motif and histidine/aspartic domain–containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4+ T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682–1687).

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Figure 1: SAMHD1 restricts HIV-1 replication in resting CD4+ T cells by reducing dNTP concentrations needed for reverse transcription.

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Correspondence to Nan Yan or Judy Lieberman.

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Yan, N., Lieberman, J. SAMHD1 does it again, now in resting T cells. Nat Med 18, 1611–1612 (2012). https://doi.org/10.1038/nm.2980

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