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Attacking the flank: targeting new pathways in SBMA

Androgen withdrawal–based therapeutic strategies for spinal and bulbar muscular atrophy (SBMA) have shown limited benefit in clinical trials, and therapies for this disease still remain a considerable challenge. The finding that a class of migraine medications, the triptans, improve disease in a mouse model of SBMA suggests a new route for future investigations into SBMA therapies (pages 1531–1538).

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Figure 1: Targeting CGRP1 upregulation in SBMA using naratriptan.

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Correspondence to Diane E Merry.

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Merry, D. Attacking the flank: targeting new pathways in SBMA. Nat Med 18, 1461–1463 (2012). https://doi.org/10.1038/nm.2967

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