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Attacking the flank: targeting new pathways in SBMA

Androgen withdrawal–based therapeutic strategies for spinal and bulbar muscular atrophy (SBMA) have shown limited benefit in clinical trials, and therapies for this disease still remain a considerable challenge. The finding that a class of migraine medications, the triptans, improve disease in a mouse model of SBMA suggests a new route for future investigations into SBMA therapies (pages 1531–1538).

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Figure 1: Targeting CGRP1 upregulation in SBMA using naratriptan.


  1. La Spada, A.R., Wilson, E.M., Lubahn, D.B., Harding, A.E. & Fischbeck, K.H. Nature 352, 77–79 (1991).

    Article  CAS  Google Scholar 

  2. Kennedy, W.R., Alter, M. & Sung, J.H. Neurology 18, 671–680 (1968).

    Article  CAS  Google Scholar 

  3. Sobue, G. et al. Brain 112, 209–232 (1989).

    Article  Google Scholar 

  4. Chevalier-Larsen, E.S. et al. J. Neurosci. 24, 4778–4786 (2004).

    Article  CAS  Google Scholar 

  5. Katsuno, M. et al. Neuron 35, 843–854 (2002).

    Article  CAS  Google Scholar 

  6. Takeyama, K. et al. Neuron 35, 855–864 (2002).

    Article  CAS  Google Scholar 

  7. Fernández-Rhodes, L.E. et al. Lancet Neurol. 10, 140–147 (2011).

    Article  Google Scholar 

  8. Katsuno, M. et al. Lancet Neurol. 9, 875–884 (2010).

    Article  CAS  Google Scholar 

  9. Rhodes, L.E. et al. Brain 132, 3242–3251 (2009).

    Article  Google Scholar 

  10. Montie, H.L. et al. Hum. Mol. Genet. 18, 1937–1950 (2009).

    Article  CAS  Google Scholar 

  11. Nedelsky, N.B. et al. Neuron 67, 936–952 (2010).

    Article  CAS  Google Scholar 

  12. Orr, C.R. et al. J. Biol. Chem. 285, 35567–35577 (2010).

    Article  CAS  Google Scholar 

  13. Minamiyama, M. et al. Nat. Med. 18, 1531–1538 (2012).

    Article  CAS  Google Scholar 

  14. Ho, T.W., Edvinsson, L. & Goadsby, P.J. Nat. Rev. Neurol. 6, 573–582 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Diane E Merry.

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Merry, D. Attacking the flank: targeting new pathways in SBMA. Nat Med 18, 1461–1463 (2012).

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