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A complex substitute: antibody therapy for hemophilia

Deficiency of the procoagulant cofactor factor VIII (FVIII) in hemophilia A is routinely treated by protein replacement therapy with plasma-derived or recombinant FVIII. Now, a humanized bispecific antibody has been demonstrated to perform the 'scaffold' function of FVIII and could potentially function as a FVIII substitute as a treatment for this inherited bleeding condition (pages 1570–1574).

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Figure 1: A bispecific antibody therapy to restore cofactor activity in the intrinsic tenase complex in hemophilia A.


  1. World Federation of Hemophilia. World Federation of Hemophilia Report on the Annual Global Survey 2010. <> (2010).

  2. Bolton-Maggs, P.H. & Pasi, K.J. Lancet 361, 1801–1809 (2003).

    Article  CAS  Google Scholar 

  3. Key, N.S. & Negrier, C. Lancet 370, 439–448 (2007).

    Article  CAS  Google Scholar 

  4. Mei, B. et al. Blood 116, 270–279 (2010).

    Article  CAS  Google Scholar 

  5. Powell, J.S. et al. Blood 119, 3031–3037 (2012).

    Article  CAS  Google Scholar 

  6. Kitazawa, T. et al. Nat. Med. 18, 1570–1574 (2012).

    Article  CAS  Google Scholar 

  7. Nilsson, I.M., Berntorp, E., Lofqvist, T. & Pettersson, H. J. Intern. Med. 232, 25–32 (1992).

    Article  CAS  Google Scholar 

  8. Manco-Johnson, M.J. et al. N. Engl. J. Med. 357, 535–544 (2007).

    Article  CAS  Google Scholar 

  9. Hay, C.R.M. et al. Blood 117, 6367–6370 (2011).

    Article  CAS  Google Scholar 

  10. Astermark, J. et al. Blood 109, 546–551 (2007).

    Article  CAS  Google Scholar 

  11. Fay, P.J. Blood Rev. 18, 1–15 (2004).

    Article  Google Scholar 

  12. De Groot, A.S. & Moise, L. Curr. Opin. Drug Discov. Devel. 10, 332–340 (2007).

    CAS  PubMed  Google Scholar 

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Correspondence to David Lillicrap.

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Lillicrap, D. A complex substitute: antibody therapy for hemophilia. Nat Med 18, 1460–1461 (2012).

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