Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

LIF-ting Hippo averts metastasis

Reactivation of 'metastasis suppressor' genes holds great promise for the treatment of incurable malignancies. To date, only a few of these genes have been identified. A new study shows that breast cancer metastasis can be blunted by leukemia inhibitory factor (LIF) signaling through regulation of the Hippo pathway, linking metastatic growth to the regulation of a pathway involved in building organs during development (pages 1511–1517).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: LIFR is an upstream regulator of the Hippo pathway.


  1. Steeg, P.S. & Theodorescu, D. Nat. Clin. Pract. Oncol. 5, 206–219 (2008).

    Article  CAS  Google Scholar 

  2. Chen, D. et al. Nat. Med. 18, 1511–1517 (2012).

    Article  CAS  Google Scholar 

  3. Pan, D. Dev. Cell 19, 491–505 (2010).

    Article  CAS  Google Scholar 

  4. Dupont, S. et al. Nature 474, 179–183 (2011).

    Article  CAS  Google Scholar 

  5. Halder, G., Dupont, S. & Piccolo, S. Nat. Rev. Mol. Cell Biol. 13, 591–600 (2012).

    Article  CAS  Google Scholar 

  6. Ramos, A. & Camargo, F.D. Trends Cell Biol. 22, 339–346 (2012).

    Article  CAS  Google Scholar 

  7. Egeblad, M., Nakasone, E.S. & Werb, Z. Dev. Cell 18, 884–901 (2010).

    Article  CAS  Google Scholar 

  8. Cordenonsi, M. et al. Cell 147, 759–772 (2011).

    Article  CAS  Google Scholar 

  9. Ma, L. et al. Nat. Cell Biol. 12, 247–256 (2010).

    Article  CAS  Google Scholar 

  10. Chaffer, C.L. & Weinberg, R.A. Science 331, 1559–1564 (2011).

    Article  CAS  Google Scholar 

  11. Quaglino, A., Schere-Levy, C., Romorini, L., Meiss, R.P. & Kordon, E.C. Breast Cancer Res. 9, R69 (2007).

    Article  Google Scholar 

  12. Lian, I. et al. Genes Dev. 24, 1106–1118 (2010).

    Article  CAS  Google Scholar 

  13. Zhan, L. et al. Cell 135, 865–878 (2008).

    Article  CAS  Google Scholar 

  14. Zhuang, G. et al. EMBO J. 31, 3513–3523 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Stefano Piccolo.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piccolo, S. LIF-ting Hippo averts metastasis. Nat Med 18, 1463–1465 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer