The long reach of liver transplantation

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Figure 1: Three early approaches to liver transplantation.
Figure 2: Early successes of liver transplantation.
Figure 3: Stepwise immunosuppression-associated improvements in liver-transplant survival.
Figure 4
Figure 5: The kinetics of immunosuppression-aided exhaustion and deletion of host-versus-graft (HvG) and graft-versus-host (GvH) responses occurring contemporaneously in organ recipients after migration of the graft's passenger leukocytes.

References

  1. 1

    Starzl, T.E., Kaupp, H.A. Jr., Brock, D.R., Lazarus, R.E. & Johnson, R.V. Reconstructive problems in canine liver homotransplantation with special reference to the postoperative role of hepatic venous flow. Surg. Gynecol. Obstet. 111, 733–743 (1960).

  2. 2

    Starzl, T.E., Kaupp, H.A. Jr., Brock, D.R., Butz, G.W. Jr. & Linman, J.W. Homotransplantation of multiple visceral organs. Am. J. Surg. 103, 219–229 (1962).

  3. 3

    Starzl, T.E. et al. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg. Gynecol. Obstet. 137, 179–199 (1973).

  4. 4

    Starzl, T.E. et al. Homotransplantation of the liver in humans. Surg. Gynecol. Obstet. 117, 659–676 (1963).

  5. 5

    Starzl, T.E. et al. Orthotopic homotransplantation of the human liver. Ann. Surg. 168, 392–415 (1968).

  6. 6

    Starzl, T.E. Experience in Hepatic Transplantation (WB Saunders Company, Philadelphia, PA, 1969).

  7. 7

    Starzl, T.E., Klintmalm, G.B.G., Porter, K.A., Iwatsuki, S. & Schroter, G.P.J. Liver transplantation with use of cyclosporin A and prednisone. N. Engl. J. Med. 305, 266–269 (1981).

  8. 8

    Starzl, T.E. et al. FK 506 for human liver, kidney and pancreas transplantation. Lancet 334, 1000–1004 (1989).

  9. 9

    Starzl, T.E. et al. Cell migration, chimerism, and graft acceptance. Lancet 339, 1579–1582 (1992).

  10. 10

    Starzl, T.E. & Zinkernagel, R. Antigen localization and migration in immunity and tolerance. N. Engl. J. Med. 339, 1905–1913 (1998).

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Correspondence to Thomas E Starzl.

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Starzl, T. The long reach of liver transplantation. Nat Med 18, 1489–1492 (2012). https://doi.org/10.1038/nm.2927

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