T cells responding to tumor cells and chronic viral pathogens are ineffective because their function is suppressed by inhibitory receptors such as Tim-3. New work identifies the first component of the Tim-3 inhibitory signaling pathway in T cells (pages 1394–1400).
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Haining, W. Thinking inside the box: how T cell inhibitory receptors signal. Nat Med 18, 1338–1339 (2012). https://doi.org/10.1038/nm.2921
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DOI: https://doi.org/10.1038/nm.2921
