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A ROSy future for metabolic regulation of HSC division

Nature Medicine volume 18, pages 13341336 (2012) | Download Citation

Unraveling the intracellular networks that regulate the self-renewal and differentiation of hematopoietic stem cells (HSCs) is crucial to enhancing the efficacy of these therapeutic transplantable cells. A newly discovered pathway links a leukemia tumor suppressor gene with a nutrient sensor to regulate fatty-acid oxidation (FAO) and stem cell division—information with the potential for modulating hematopoiesis for clinical advantage (pages 1350–1358).

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Author information

Affiliations

  1. Hal E. Broxmeyer and Charlie Mantel are in the Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

    • Hal E Broxmeyer
    •  & Charlie Mantel

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Hal E Broxmeyer.

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DOI

https://doi.org/10.1038/nm.2917

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