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A ROSy future for metabolic regulation of HSC division

Nature Medicine volume 18, pages 1334–1336 (2012)Cite this article

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Unraveling the intracellular networks that regulate the self-renewal and differentiation of hematopoietic stem cells (HSCs) is crucial to enhancing the efficacy of these therapeutic transplantable cells. A newly discovered pathway links a leukemia tumor suppressor gene with a nutrient sensor to regulate fatty-acid oxidation (FAO) and stem cell division—information with the potential for modulating hematopoiesis for clinical advantage (pages 1350–1358).

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Figure 1: The PML–PPAR-δ–FAO pathway influences ROS generation and HSC division.

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Authors and Affiliations

  1. Hal E. Broxmeyer and Charlie Mantel are in the Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.,

    Hal E Broxmeyer & Charlie Mantel

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  1. Hal E Broxmeyer
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  2. Charlie Mantel
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Correspondence to Hal E Broxmeyer.

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The authors declare no competing financial interests.

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Broxmeyer, H., Mantel, C. A ROSy future for metabolic regulation of HSC division. Nat Med 18, 1334–1336 (2012). https://doi.org/10.1038/nm.2917

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