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A sweet spot to control complement-induced inflammation

Nature Medicine volume 18, pages 13401341 (2012) | Download Citation

Complement is intricately involved in inflammatory processes, yet the mechanisms that modulate the actions of its key mediator C5a are poorly understood. A new study uncovers a molecular partnership between three neutrophil receptors in the recognition of differentially glycated immune complexes and sheds light on regulatory processes in autoimmune and inflammatory disorders (pages 1401–1406).

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Author information

Affiliations

  1. Daniel Ricklin, Edimara S. Reis and John D. Lambris are in the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Daniel Ricklin
    • , Edimara S Reis
    •  & John D Lambris

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Competing interests

The authors declare no competing financial interests.

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Correspondence to John D Lambris.

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DOI

https://doi.org/10.1038/nm.2916

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