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Technical concerns about immunoprecipitation of methylated fetal DNA for noninvasive trisomy 21 diagnosis

Nature Medicine volume 18, pages 13271328 (2012) | Download Citation

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Acknowledgements

This project was supported by the University Grants Committee of the Government of the Hong Kong Special Administration Region, China—Areas of Excellence Scheme (AoE/M-04/06). We thank A. Cheng, S. Lau, L. Lu and P. Jiang for helpful discussions.

Author information

Affiliations

  1. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

    • Yu Kwan Tong
    • , Rossa Wai Kwun Chiu
    • , Kwan Chee Allen Chan
    •  & Yuk Ming Dennis Lo
  2. Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

    • Yu Kwan Tong
    • , Rossa Wai Kwun Chiu
    • , Kwan Chee Allen Chan
    •  & Yuk Ming Dennis Lo
  3. Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

    • Tak Yeung Leung

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Competing interests

All authors hold or have filed patent applications on aspects of noninvasive prenatal diagnosis. Part of this patent portfolio has been licensed to Sequenom. Y.M.D.L. and R.W.K.C. are consultants to, hold equities in, and receive research support from Sequenom.

Corresponding author

Correspondence to Yuk Ming Dennis Lo.

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    Supplementary Tables 1–4, Supplementary Figure 1 and Supplementary Methods

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DOI

https://doi.org/10.1038/nm.2915

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