TRP-ing up brain tumors

Malignant gliomas are devastating, uniformly fatal cancers for which current therapies remain palliative. A new study in mice shows that neural precursor cells, abundant in neonatal brains, release a fatty acid factor that induces glioma cell death through the activation of TRPV1 channels, prolonging survival and potentially uncovering a new treatment strategy (pages 1232–1238).

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Figure 1: NPCs induce glioma cell death via TRPV1 channels.

Katie Vicari

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Correspondence to Jeremy N Rich.

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Schonberg, D., Bao, S. & Rich, J. TRP-ing up brain tumors. Nat Med 18, 1175–1176 (2012). https://doi.org/10.1038/nm.2894

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