Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

TRP-ing up brain tumors

Malignant gliomas are devastating, uniformly fatal cancers for which current therapies remain palliative. A new study in mice shows that neural precursor cells, abundant in neonatal brains, release a fatty acid factor that induces glioma cell death through the activation of TRPV1 channels, prolonging survival and potentially uncovering a new treatment strategy (pages 1232–1238).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: NPCs induce glioma cell death via TRPV1 channels.

Katie Vicari

References

  1. Dunn, G.P. et al. Genes Dev. 26, 756–784 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Rolle, C.E., Sengupta, S. & Lesniak, M.S. Neurosurg. Clin. N. Am. 21, 201–214 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Aboody, K.S. et al. Proc. Natl. Acad. Sci. USA 97, 12846–12851 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Stock, K. et al. Nat. Med. 18, 1232–1238 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. De Lago, E. et al. J. Neurochem. 99, 677–688 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Binello, E. & Germano, I.M. Neuro Oncol. 14, 256–265 (2012).

    Article  CAS  PubMed  Google Scholar 

  7. Amantini, C. et al. J. Neurochem. 102, 977–990 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Aboody, K. et al. Neuron 70, 597–613 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Villeda, S.A. et al. Nature 477, 90–94 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Schwartzentruber, J. et al. Nature 482, 226–231 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Jones, C., Perryman, L. & Hargrave, D. Nat. Rev. Clin. Oncol. 9, 400–413 (2012).

    Article  CAS  Google Scholar 

  12. Caterina, M.J. et al. Nature 389, 816–824 (1997).

    Article  CAS  PubMed  Google Scholar 

  13. Dhaka, A. et al. J. Neurosci. 29, 153–158 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hjelmeland, A.B. et al. Cell Death Differ. 18, 829–840 (2011).

    Article  CAS  PubMed  Google Scholar 

  15. Morelli, M.B. et al. Int. J. Cancer published online, doi:10.1002/ijc.27588 (27 April 2012).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeremy N Rich.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schonberg, D., Bao, S. & Rich, J. TRP-ing up brain tumors. Nat Med 18, 1175–1176 (2012). https://doi.org/10.1038/nm.2894

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2894

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer