Malignant gliomas are devastating, uniformly fatal cancers for which current therapies remain palliative. A new study in mice shows that neural precursor cells, abundant in neonatal brains, release a fatty acid factor that induces glioma cell death through the activation of TRPV1 channels, prolonging survival and potentially uncovering a new treatment strategy (pages 1232–1238).
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Dunn, G.P. et al. Genes Dev. 26, 756–784 (2012).
Rolle, C.E., Sengupta, S. & Lesniak, M.S. Neurosurg. Clin. N. Am. 21, 201–214 (2010).
Aboody, K.S. et al. Proc. Natl. Acad. Sci. USA 97, 12846–12851 (2000).
Stock, K. et al. Nat. Med. 18, 1232–1238 (2012).
De Lago, E. et al. J. Neurochem. 99, 677–688 (2006).
Binello, E. & Germano, I.M. Neuro Oncol. 14, 256–265 (2012).
Amantini, C. et al. J. Neurochem. 102, 977–990 (2007).
Aboody, K. et al. Neuron 70, 597–613 (2011).
Villeda, S.A. et al. Nature 477, 90–94 (2011).
Schwartzentruber, J. et al. Nature 482, 226–231 (2012).
Jones, C., Perryman, L. & Hargrave, D. Nat. Rev. Clin. Oncol. 9, 400–413 (2012).
Caterina, M.J. et al. Nature 389, 816–824 (1997).
Dhaka, A. et al. J. Neurosci. 29, 153–158 (2009).
Hjelmeland, A.B. et al. Cell Death Differ. 18, 829–840 (2011).
Morelli, M.B. et al. Int. J. Cancer published online, doi:10.1002/ijc.27588 (27 April 2012).
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Schonberg, D., Bao, S. & Rich, J. TRP-ing up brain tumors. Nat Med 18, 1175–1176 (2012). https://doi.org/10.1038/nm.2894
This article is cited by
Heat shock factor 1 in brain tumors: a link with transient receptor potential channels TRPV1 and TRPA1
Journal of Molecular Histology (2021)