Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells

Nature Medicine volume 18, pages 1456–1457 (2012)Cite this article

Subjects

To the Editor:

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Figure 1: Sensitivity of A/PR8/8/34 (H1N1) and H5N1-NS reassortant viruses to the action of IFNs.
Figure 2: Sensitivity to cytokine action of several influenza viruses used in the study by Seo et al.1.

Accession codes

Primary accessions

GenBank/EMBL/DDBJ

References

  1. Seo, S.H., Hoffman, E. & Webster, R.G. Nat. Med. 8, 950–954 (2002).

    CAS  Article  Google Scholar 

  2. Cauthen, A.N., Swayne, D.E., Sekellick, M.J., Marcus, P.I. & Suarez, D.L. J. Virol. 81, 1838–1847 (2007).

    CAS  Article  Google Scholar 

  3. Marcus, P.I., Ngunjiri, J.M., Sekellick, M.J., Wang, L. & Lee, C.-W. J. Virol. 84, 10974–10981 (2010).

    CAS  Article  Google Scholar 

  4. Sekellick, M.J., Carra, S.A., Bowman, A., Hopkins, D.A. & Marcus, P.I. J. Interferon Cytokine Res. 20, 963–970 (2000).

    CAS  Article  Google Scholar 

  5. Webster, R.G., Bean, W.J., Gorman, O.T., Chambers, T.M. & Kawaoka, Y. Microbiol. Rev. 56, 152–179 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Hayman, A. et al. J. Virol. 81, 2318–2327 (2007).

    CAS  Article  Google Scholar 

  7. Haasbach, E., Droebner, K., Vogel, A.B. & Planz, O. J. Interferon Cytokine Res. 31, 515–525 (2011).

    CAS  Article  Google Scholar 

  8. Szretter, K.J. et al. J. Virol. 83, 5825–5834 (2009).

    CAS  Article  Google Scholar 

  9. Marcus, P.I. & Yoshida, I. J. Cell. Physiol. 143, 416–419 (1990).

    CAS  Article  Google Scholar 

  10. Silversides, D.W., Music, N., Jaques, M., Gagnon, C.A. & Webby, R. J. Virol. 84, 5454–5455 (2010).

    CAS  Article  Google Scholar 

  11. Herfst, S. et al. Science 336, 1534–1541 (2012).

    CAS  Article  Google Scholar 

  12. Imai, M. et al. Nature 486, 420–428 (2012).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

This work was supported by a donation to the Virus and Interferon Research Laboratory (P.I.M. and M.J.S.), by the US National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Department of Health and Human Services, contract number HSN266200700005C and by the American Lebanese Syrian Associated Charities (R.G.W. and S.S.-C.).

Author information

Author notes

  1. Kareem N Mohni

    Present address: Current address: Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.,

Authors and Affiliations

  1. Department of Molecular and Cell Biology, Virus and Interferon Research Laboratory, University of Connecticut, Storrs, Connecticut, USA

    John M Ngunjiri, Kareem N Mohni, Margaret J Sekellick & Philip I Marcus

  2. Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

    Stacey Schultz-Cherry & Robert G Webster

Authors
  1. John M Ngunjiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kareem N Mohni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Margaret J Sekellick
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stacey Schultz-Cherry
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert G Webster
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Philip I Marcus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philip I Marcus.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ngunjiri, J., Mohni, K., Sekellick, M. et al. Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells. Nat Med 18, 1456–1457 (2012). https://doi.org/10.1038/nm.2879

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2879

Further reading

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing