There is currently much interest in dissecting the mechanisms of tumor immunity. A new study shows that a subset of CD4+ T cells that produce the cytokine interleukin-9 (IL-9) mediate inhibition of melanoma growth in mice and that analogous IL-9–producing T cells are present in human skin (pages 1248–1253). Could such cells be manipulated to develop new therapeutic strategies for melanoma?
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Katie Vicari
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Zou, W., Restifo, N. Nine lives for TH9s?. Nat Med 18, 1177–1178 (2012). https://doi.org/10.1038/nm.2868
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DOI: https://doi.org/10.1038/nm.2868
