MicroRNAs (miRNAs) have emerged as crucial mediators of human disease, but their roles in autoimmunity have only recently been appreciated. A new study using mouse and human tissues from various interleukin-17 (IL-17)-related autoimmune disorders now shows that miRNA-23b is a central regulator of inflammation in resident tissue cells during autoimmunity (pages 1077–1086).
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Hu, R., O'Connell, R. MiR-23b is a safeguard against autoimmunity. Nat Med 18, 1009–1010 (2012). https://doi.org/10.1038/nm.2849
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DOI: https://doi.org/10.1038/nm.2849
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