The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion

The bone marrow niche keeps puzzling scientists in cancer and regenerative medicine. What elements constitute the niche and how it affects neighbor cells in different disease contexts remain to be a matter of debate and extensive investigation. The translational use of hematopoietic stem cells (HSCs) in transplantation biology poses a challenge, given the propensity of these cells to remain quiescent. Although the niche is a good candidate to exploit for reprogramming HSCs and controlling their expansion, new studies have added to its complexity. In 'Bench to Bedside', Paul S. Frenette and Yuya Kunisaki examine these studies to discuss how new players and their signals are involved in HSC maintenance and what the implications are for the development of HSC-based therapies. Among the alterations occurring in leukemias, metabolic events seem to foster cancer progression but may also be involved in cancer predisposition. Rushdia Z. Yusuf, Ying-Hua Wang and David T. Scadden peruse recent clinical and experimental studies that look at myelodysplastic syndromes and secondary leukemias and argue how metabolic changes in these cancers may not only be cell autonomous but also can emanate from the bone marrow stroma. Targeting this niche may open new avenues to reduce the risk for secondary leukemias in cancer survivors.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The complex cellular and molecular make up of the HSC niche in the bone marrow.

References

  1. 1

    Brunstein, C.G. et al. Blood 116, 4693–4699 (2010).

  2. 2

    Schofield, R. Blood Cells 4, 7–25 (1978).

  3. 3

    Byrd, D.T. & Kimble, J. Semin. Cell Dev. Biol. 20, 1107–1113 (2009).

  4. 4

    Scadden, D.T. Nature 441, 1075–1079 (2006).

  5. 5

    Sugiyama, T., Kohara, H., Noda, M. & Nagasawa, T. Immunity 25, 977–988 (2006).

  6. 6

    Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).

  7. 7

    Yamazaki, S. et al. Cell 147, 1146–1158 (2011).

  8. 8

    Ding, L., Saunders, T.L., Enikolopov, G. & Morrison, S.J. Nature 481, 457–462 (2012).

  9. 9

    Pietras, E.M., Warr, M.R. & Passegue, E. J. Cell Biol. 195, 709–720 (2011).

  10. 10

    Yamazaki, S. et al. Blood 113, 1250–1256 (2009).

  11. 11

    Katayama, Y. et al. Cell 124, 407–421 (2006).

  12. 12

    Broudy, V.C. Blood 90, 1345–1364 (1997).

Download references

Author information

Correspondence to Paul S Frenette.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kunisaki, Y., Frenette, P. The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion. Nat Med 18, 864–865 (2012). https://doi.org/10.1038/nm.2825

Download citation

Further reading