Melanoma exosomes: messengers of metastasis

A new study shows that melanoma-derived exosomes contribute to metastatic invasion by carrying messenger proteins that direct bone marrow–derived cells toward a prometastatic phenotype. This leads to the promotion of proangiogenic events and modification of the extracellular matrix at premetastatic sites (pages 883–891).

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Figure 1: Melanoma-derived exosomes are messengers for angiogenesis and metastatic invasion.


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Correspondence to Meenhard Herlyn.

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The authors declare no competing financial interests.

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Somasundaram, R., Herlyn, M. Melanoma exosomes: messengers of metastasis. Nat Med 18, 853–854 (2012).

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