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King of hearts: a splicing factor rules cardiac proteins

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766–773).

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Figure 1: Loss-of-function mutations in the splicing factor RBM20 cause dilated cardiomyopathy via the pathological splicing of cardiac proteins.


  1. Herman, D.S. et al. N. Engl. J. Med. 366, 619–628 (2012).

    Article  CAS  Google Scholar 

  2. Guo, W. et al. Nat. Med. 18, 766–773 (2012).

    Article  CAS  Google Scholar 

  3. Brauch, K.M. et al. J. Am. Coll. Cardiol. 54, 930–941 (2009).

    Article  CAS  Google Scholar 

  4. Greaser, M.L. et al. J. Mol. Cell. Cardiol. 44, 983–991 (2008).

    Article  CAS  Google Scholar 

  5. Opitz, C.A., Leake, M.C., Makarenko, I., Benes, V. & Linke, W.A. Circ. Res. 94, 967–975 (2004).

    Article  CAS  Google Scholar 

  6. Refaat, M.M. et al. Heart Rhythm 9, 390–396 (2012).

    Article  Google Scholar 

  7. Taylor, M. et al. Circulation 124, 876–885 (2011).

    Article  Google Scholar 

  8. Makarenko, I. et al. Circ. Res. 95, 708–716 (2004).

    Article  CAS  Google Scholar 

  9. Kong, S.W. et al. Circ. Cardiovasc. Genet. 3, 138–146 (2010).

    Article  CAS  Google Scholar 

  10. Wang, E.T. et al. Nature 456, 470–476 (2008).

    Article  CAS  Google Scholar 

  11. Ding, J.H. et al. EMBO J. 23, 885–896 (2004).

    Article  CAS  Google Scholar 

  12. Xu, X. et al. Cell 120, 59–72 (2005).

    Article  CAS  Google Scholar 

  13. Macrae, C.A. & McKenna, W.J. J. Am. Coll. Cardiol. 54, 942–943 (2009).

    Article  Google Scholar 

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Correspondence to Wolfgang A Linke.

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Linke, W., Bücker, S. King of hearts: a splicing factor rules cardiac proteins. Nat Med 18, 660–661 (2012).

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