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Protective inflammasome activation in AMD

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. AMD progression is associated with alterations in inflammatory pathways and the immune system. A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791–798).

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Figure 1: Inflammasome-mediated regulation of choroidal neovascularization in AMD.

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Correspondence to Lois E H Smith.

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Chen, J., Smith, L. Protective inflammasome activation in AMD. Nat Med 18, 658–660 (2012). https://doi.org/10.1038/nm.2761

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