Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neighborhood watch orchestrates liver regeneration

Liver injury promotes the outgrowth of cell types that are relatively rare in healthy livers, including progenitors and stromal cells. A new study shows that the type of injury influences the cellular composition of the liver progenitor niche, which then seems to direct the fate of progenitors during regeneration (pages 572–579).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Type of liver injury influences cellular composition of the progenitor niche to direct progenitor fate during regeneration.


  1. Duncan, A.W., Dorrell, C. & Grompe, M. Gastroenterology 137, 466–481 (2009).

    Article  Google Scholar 

  2. Michalopoulos, G.K. Am. J. Pathol. 176, 2–13 (2010).

    CAS  Article  Google Scholar 

  3. Boulter, L. et al. Nat. Med. 18, 572–579 (2012).

    CAS  Article  Google Scholar 

  4. Zhang, L., Theise, N., Chua, M. & Reid, L.M. Hepatology 48, 1598–1607 (2008).

    CAS  Article  Google Scholar 

  5. Lorenzini, S. et al. Gut 59, 645–654 (2010).

    Article  Google Scholar 

  6. Roskams, T. & Desmet, V. Semin. Diagn. Pathol. 15, 259–269 (1998).

    CAS  Google Scholar 

  7. Omenetti, A., Choi, S., Michelotti, G. & Diehl, A.M. J. Hepatol. 54, 366–373 (2011).

    CAS  Article  Google Scholar 

  8. Hofmann, J.J. et al. Development 137, 4061–4072 (2010).

    CAS  Article  Google Scholar 

  9. Traver, D. et al. Blood 98, 627–635 (2001).

    CAS  Article  Google Scholar 

  10. Zaret, K.S. & Grompe, M. Science 322, 1490–1494 (2008).

    CAS  Article  Google Scholar 

  11. Harris, P.J., Speranza, G. & Dansky Ullmann, C. Expert Opin. Ther. Targets 16, 131–145 (2012).

    CAS  Article  Google Scholar 

  12. Deutsch, G., Jung, J., Zheng, M., Lora, J. & Zaret, K.S. Development 128, 871–881 (2001).

    CAS  Google Scholar 

  13. Katoh, M. Curr. Pharm. Biotechnol. 12, 160–170 (2011).

    CAS  Article  Google Scholar 

  14. Katoh, Y. & Katoh, M. Int. J. Oncol. 33, 881–886 (2008).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Anna Mae Diehl.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Diehl, A. Neighborhood watch orchestrates liver regeneration. Nat Med 18, 497–499 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing