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Neighborhood watch orchestrates liver regeneration

Liver injury promotes the outgrowth of cell types that are relatively rare in healthy livers, including progenitors and stromal cells. A new study shows that the type of injury influences the cellular composition of the liver progenitor niche, which then seems to direct the fate of progenitors during regeneration (pages 572–579).

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Figure 1: Type of liver injury influences cellular composition of the progenitor niche to direct progenitor fate during regeneration.

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Correspondence to Anna Mae Diehl.

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Diehl, A. Neighborhood watch orchestrates liver regeneration. Nat Med 18, 497–499 (2012). https://doi.org/10.1038/nm.2719

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