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Cancer-fighting Smurf

Nature Medicine volume 18, pages 204205 (2012) | Download Citation

A newly identified role for SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) in the regulation of histone ubiquitination uncovers a broad tumor suppressor activity that helps to maintain genomic stability in mice. A recent study suggests a new mechanism underlying the role of ubiquitination in cancer (pages 227–234).

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Author information

Affiliations

  1. Xi Wang and Charles W. M. Roberts are at the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

    • Xi Wang
    •  & Charles W M Roberts

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Charles W M Roberts.

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DOI

https://doi.org/10.1038/nm.2655

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