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The road to resistance: EGFR mutation and cetuximab

Some individuals with colorectal cancer benefit from therapies targeting the epidermal growth factor receptor (EGFR). However, resistance to EGFR blockade inevitably occurs. The characterization of a new mechanism of resistance to the EGFR-specific antibody cetuximab provides clues into how therapeutic strategies might be designed to overcome this specific resistance mechanism (pages 221–223).

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Figure 1: Cetuximab sensitivity and resistance.

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Correspondence to Pasi A Jänne.

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Bardelli, A., Jänne, P. The road to resistance: EGFR mutation and cetuximab. Nat Med 18, 199–200 (2012). https://doi.org/10.1038/nm.2646

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