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Building bones by knocking down genes

Nature Medicine volume 18, pages 202–204 (2012)Cite this article

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New strategies for selectively stimulating bone formation without promoting bone resorption are required, as all currently approved agents for osteoporosis act on both of these aspects of the bone remodeling process. A recent study describes an approach that specifically delivers therapeutic siRNAs to bone-forming surfaces without affecting bone resorption (pages 307–314).

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Figure 1: Targeting an siRNA-based therapeutic specifically to the BMU.

Katie Vicari

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  1. Clifford J. Rosen is at the Maine Medical Center Research Institute, Scarborough, Maine, USA.,

    Clifford J Rosen

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  1. Clifford J Rosen
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Correspondence to Clifford J Rosen.

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Rosen, C. Building bones by knocking down genes. Nat Med 18, 202–204 (2012). https://doi.org/10.1038/nm.2630

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