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The problems and promises of research into human immunology and autoimmune disease

Nature Medicine volume 18, pages 48–53 (2012)Cite this article

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Translational research in autoimmunity is hampered by a number of hurdles, including a lack of knowledge regarding initiating and pathologically relevant autoantigens, the low frequency of autoreactive pathogenic B and T cells, difficulty in accessing the affected tissue, differences between self-reactive and pathogen-specific lymphocytes, a lack of etiologically relevant preclinical animal models and the heterogeneity of disease presentation. Given the need for biomarkers and new therapeutics, it is imperative that these hurdles be surmounted.

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Authors and Affiliations

  1. Department of Immunohaematology and Blood Transfusion, Bart O. Roep is at the Leiden University Medical Center, National Diabetes Expert Center, Leiden, The Netherlands.,

    Bart O Roep

  2. Jane Buckner is at the Translational Research Program, Benaroya Research Institute, Seattle, Washington, USA.,

    Jane Buckner

  3. Department of Clinical Neuroscience, Stephen Sawcer is at the University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.,

    Stephen Sawcer

  4. Rene Toes is at the Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.,

    Rene Toes

  5. Frauke Zipp is at the Klinik und Poliklinik für Neurologie, Universitätsmedizin Mainz (University Medical Center), Johannes-Gutenberg-Universität Mainz, Mainz, Germany.,

    Frauke Zipp

Authors
  1. Bart O Roep
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  4. Rene Toes
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  5. Frauke Zipp
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Correspondence to Bart O Roep.

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Roep, B., Buckner, J., Sawcer, S. et al. The problems and promises of research into human immunology and autoimmune disease. Nat Med 18, 48–53 (2012). https://doi.org/10.1038/nm.2626

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