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Finding a sirtuin truth in Huntington's disease

Nature Medicine volume 18, pages 2426 (2012) | Download Citation

The search for compounds to treat neurodegenerative disorders is especially pressing given the rapidly growing elderly human population and has led to the consideration of sirtuin proteins as potential therapeutic candidates. Two studies now report that modulating the expression of the sirtuin Sirt1 has therapeutic benefit in Huntington's disease mouse models and identify putative downstream targets of Sirt1 involved in improved disease outcomes (pages 159–165 and 153–158).

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Author information

Affiliations

  1. Albert R. La Spada is in the Departments of Pediatrics, Cellular & Molecular Medicine, and Neurosciences, Division of Biological Science, University of California–San Diego, La Jolla, California, USA, and the Institute for Genomic Medicine, University of California–San Diego, La Jolla, California, USA.

    • Albert R La Spada

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The author declares no competing financial interests.

Corresponding author

Correspondence to Albert R La Spada.

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DOI

https://doi.org/10.1038/nm.2624

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