The search for compounds to treat neurodegenerative disorders is especially pressing given the rapidly growing elderly human population and has led to the consideration of sirtuin proteins as potential therapeutic candidates. Two studies now report that modulating the expression of the sirtuin Sirt1 has therapeutic benefit in Huntington's disease mouse models and identify putative downstream targets of Sirt1 involved in improved disease outcomes (pages 159–165 and 153–158).
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La Spada, A. Finding a sirtuin truth in Huntington's disease. Nat Med 18, 24–26 (2012). https://doi.org/10.1038/nm.2624
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DOI: https://doi.org/10.1038/nm.2624
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