Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individuals with autoimmune disease.
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Change history
05 April 2012
In the version of this article initially published, the affiliation of one author (R.M.R.) was incorrectly listed. The correct affiliation is Lerner Research Institute and Mellen Center for Multiple Sclerosis Treatment and Research (Neurological Institute). The error has been corrected in the HTML and PDF versions of the article.
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Sakaguchi, S., Powrie, F. & Ransohoff, R. Re-establishing immunological self-tolerance in autoimmune disease. Nat Med 18, 54–58 (2012). https://doi.org/10.1038/nm.2622
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DOI: https://doi.org/10.1038/nm.2622
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