Commentary | Published:

Dysregulation of immune homeostasis in autoimmune diseases

Nature Medicine volume 18, pages 4247 (2012) | Download Citation

Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury.

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Author information

Affiliations

  1. Vijay K. Kuchroo is at the Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • Vijay K Kuchroo
  2. Pamela S. Ohashi is at the Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada.

    • Pamela S Ohashi
  3. R. Balfour Sartor is at the Departments of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • R Balfour Sartor
  4. Carola G. Vinuesa is at the John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

    • Carola G Vinuesa

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Vijay K Kuchroo.

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DOI

https://doi.org/10.1038/nm.2621

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