Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Diagnosis in a dish: your skin can help your brain

The discovery that skin cells from an adult human can be reprogrammed back to their embryonic stage and then differentiated to produce neuron-like cells in culture opens an opportunity to study disease pathogenesis and screen potential therapeutic drugs. A new study provides an example of this approach for the neuropsychiatric disorder Timothy syndrome (pages 1657–1662).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: A basic strategy for generating, analyzing and using iPSCs to study genetic disease.

References

  1. Breunig, J.J., Haydar, T.F. & Rakic, P. Neuron 70, 614–625 (2011).

    Article  CAS  Google Scholar 

  2. Takahashi, K., Okita, K., Nakagawa, M. & Yamanaka, S. Nat. Protoc. 2, 3081–3089 (2007).

    Article  CAS  Google Scholar 

  3. Park, I.H. et al. Cell 134, 877–886 (2008).

    Article  CAS  Google Scholar 

  4. Maherali, N. et al. Cell Stem Cell 1, 55–70 (2007).

    Article  CAS  Google Scholar 

  5. Brennand, K.J. et al. Nature 473, 221–225 (2011).

    Article  CAS  Google Scholar 

  6. Apostolou, E. & Hochedlinger, K. Nature 474, 165–166 (2011).

    Article  CAS  Google Scholar 

  7. Paşca, S.P. et al. Nat. Med. 17, 1657–1662 (2011).

    Article  Google Scholar 

  8. Casanova, M.F., El-Baz, A., Vanbogaert, E., Narahari, P. & Switala, A. Brain Pathol. 20, 451–458 (2010).

    Article  Google Scholar 

  9. Hardan, A.Y. et al. Psychiatry Res. Neuroimaging 174, 57–61 (2009).

    Article  Google Scholar 

  10. Raznahan, A. Cereb. Cortex 20, 1332–1340 (2010).

    Article  Google Scholar 

  11. Rakic, P. Nat. Rev. Neurosci. 10, 724–735 (2009).

    Article  CAS  Google Scholar 

  12. Kang, H.J. et al. Nature 478, 483–489 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pasko Rakic.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Huttner, A., Rakic, P. Diagnosis in a dish: your skin can help your brain. Nat Med 17, 1558–1559 (2011). https://doi.org/10.1038/nm.2599

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2599

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing