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Stressed tumor cell, chemosensitized cancer

miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost tumor growth but also sensitize tumor cells to chemotherapy (pages 1627–1635).

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Figure 1: miR-200 miRNAs expression influences sensitivity to chemotherapeutic agents used in the treatment of ovarian cancer in various ways.

Marina Corral


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Correspondence to Erik A C Wiemer.

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Wiemer, E. Stressed tumor cell, chemosensitized cancer. Nat Med 17, 1552–1554 (2011).

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