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Stressed tumor cell, chemosensitized cancer

Nature Medicine volume 17, pages 1552–1554 (2011)Cite this article

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miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost tumor growth but also sensitize tumor cells to chemotherapy (pages 1627–1635).

The relatively well-studied miR-200 family—comprising miRs 141, 200a, 200b, 200c and 429—has been associated with the formation of cancer stem cells1 and is intimately involved in the epithelial-to-mesenchymal transition (EMT)2. The miR-200 family is aberrantly expressed in epithelial ovarian cancer, with increased levels observed in various histotypes (serous, endometrioid and clear cell subtypes)3,4; however, how these miRNAs function in ovarian cancer pathogenesis is still unclear.

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Figure 1: miR-200 miRNAs expression influences sensitivity to chemotherapeutic agents used in the treatment of ovarian cancer in various ways.

Marina Corral

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  1. Department of Medical Oncology, Erik A.C. Wiemer is at the Erasmus Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.,

    Erik A C Wiemer

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Correspondence to Erik A C Wiemer.

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Wiemer, E. Stressed tumor cell, chemosensitized cancer. Nat Med 17, 1552–1554 (2011). https://doi.org/10.1038/nm.2593

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