miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost tumor growth but also sensitize tumor cells to chemotherapy (pages 1627–1635).
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Wiemer, E. Stressed tumor cell, chemosensitized cancer. Nat Med 17, 1552–1554 (2011). https://doi.org/10.1038/nm.2593
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DOI: https://doi.org/10.1038/nm.2593